【摘 要】
:
Natural products have been played an important role in the development of novel cancer chemotherapeutic agents.In our program to identify anticancer agents
【机 构】
:
College of Pharmacy Ewha Womans University Korea
【出 处】
:
BIT Life Sciences' 1st Annual World Cancer Congess-2008(
论文部分内容阅读
Natural products have been played an important role in the development of novel cancer chemotherapeutic agents.In our program to identify anticancer agents from plant extracts, we found the extract of the root of Cynanchum paniculatum (Asclepiadaceae) exhibited potent antiproliferative effects in cultured human cancer cells.Bioassayguided fractionation further led to isolate the bioactive constituent and was elucidated as antofine, a phenanthroimdolizidine alkaloid.Antofine markedly inhibited the growth of several human cancer cells with the IC50 values ranging 6 to 30 nM.With the potential antiproliferative effects against cancer cells we developed the procedure of total synthesis of antofine and further investigated the antiproliferative mechanisms and anticancer effects.
其他文献
Deregulation of Myc-family oncoproteins/transcription factors is frequently observed in human cancers and often strongly correlates with poor prognosis, emp
Despite the success of endocrine therapy for estrogen receptor α positive (ER+) breast cancer, most patients develop resistance to therapy.Understanding th
神木煤田地跨陕北神木、府谷、榆林等县,面积1.3万平方公里,探明储量1531亿吨。原煤发热量6900—7200大卡/公斤,是理想的动力煤和气化用煤,在国际市场上吨煤销价35美元。神
——!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!博士!
他曾经是萨达姆政府时期的反对者,曾流亡海外;他现在是临时政府时期的外交官,赴任北京;他热爱物理与政治,但最终选择了政治作为一生中最重要的工作
He was once an opponent
启功,字元白,满族人。原姓爱新觉罗,1912年7月出生于北京。幼年丧父,过着清苦生活,未能读完中学,全靠自学成才。他年少时,力读经史辞章,并擅长绘画,后又发奋学书。他在大学
【摘要】发端于20世纪末的新一轮课程改革,是当代中国教育史上的一件大事,它从知识和能力、过程和方法、情感态度和价值观三个维度提出了关注学生成长,促进学生全面发展的全新理念,深刻影响着语文教学的每一个环节。新课程改革下小学语文作业设计,面临着重大的机遇与选择。 【关键词】新课程改革;语文教学;作业设计 【中图分类号】 G4 【文献标识码】 C【文章编号】1671-1270(2010)06-011
Xanthohumol (XN) is the major prenylated flavonoid present in the hop plant, Humulus lupulus L.(Cannabinaceae)and also a common ingredient of beer.It gained
Pancreatic cancer (PANC) is the 4th leading cause of cancer death among men and women in the United States.PANC is often dubbed the silent killer because it
[活动背景]rn2020年9月23—25日,浙江省教育厅教研室在浙江省嘉兴市海盐元济高级中学开展普通高中语文学科基地调研活动.此次活动目的是在进一步深化普通高中语文课程改革的