How T-cell resistance evolves in the course of melanoma progression

来源 :第四届中德免疫学研讨会 | 被引量 : 0次 | 上传用户：jaredchen123

【摘要】

：

【作者】

：

Fang Zhao

【机构】

：

Department of Dermatology, University Hospital, University Duisburg-Essen, Essen, Germany and German

【出处】

：

第四届中德免疫学研讨会

【发表日期】

：

2015年9期

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CD8+ T lymphocytes (CTL) can exert potent in vivo cytotoxicity against autologous melanoma cells.However, T-cell activity is impaired when poorly immunogenic tumor phenotypes evolve in the course of disease progression.Here we studied the immunogenicity of multiple consecutive metastases obtained in stage Ⅳ disease from three melanoma patients.

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How T-cell resistance evolves in the course of melanoma progression

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