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  5. The role of metal ions in Huntingtons disease

The role of metal ions in Huntingtons disease

来源 :第二届中国果蝇大会 | 被引量 : 0次 | 上传用户：zerorolove
【摘 要】
：
　　Huntingtons disease (HD) is a progressive neurodegenerative disorder caused by dominant polyglutamine expansion within the N-terminus of huntingtin protein.
【作 者】
：
Xiao Guiran Zhou Bing 
【机 构】
：
QinghuaUniversity
【出 处】
：
第二届中国果蝇大会
【发表日期】
：
2013年4期
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　　Huntingtons disease (HD) is a progressive neurodegenerative disorder caused by dominant polyglutamine expansion within the N-terminus of huntingtin protein.Metal accumulation in the striatum of HD patients has been reported for many years,but the significance of this in HD pathogenesis remains unknown.Here using a Drosophila model of HD,we screened various metal genes for their modulating effects.Two copper metabolism genes were found linked to HD pathogenesis.Our results indicate a direct link of copper with HD and suggest that decreasing copper level in the brain might provide therapeutic benefits for the treatment of this disease.
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