【摘 要】
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The HIV-1 envelope glycoproteins gpl20 and gp41 form a trimeric complex that mediates virus entry into target cells.These glycoproteins are the major target
【出 处】
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中国科协青年科学家论坛暨2006年第二届新生病毒性疾病控制学术研讨会
论文部分内容阅读
The HIV-1 envelope glycoproteins gpl20 and gp41 form a trimeric complex that mediates virus entry into target cells.These glycoproteins are the major targets for the design of vaccines and antiviral drugs.However, HIV-1 has evolved strategies to evade the host immune system or to escape from drugs.For instance, HIV-1 can use glycans to occlude highly immunogenic epitopes on envelope proteins to evade host immunity.Targeting HIV-1 glycan shields may represent a novel antiviral strategy.
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