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Thioredoxin(Trx)is an important reducing enzyme and is usually overexpressed in tumor cells.Photoactive platinum(Ⅳ)anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(Py)2](1)1-3 could bind to amino acids such as His,Glu and Gln of thioredoxin upon the irradiation of blue light.More importantly,the photoactivation also caused the oxidation of amino acids such as Met and Trp.