目的研究奥美拉唑加阿莫西林、甲硝唑治疗幽门螺杆菌阳性十二指肠溃疡的溃疡愈合率及HP根除率。方法经胃镜确诊 ,胃窦部粘膜活检证实有HP感染的活动性十二指肠溃疡 5 1例 ,随机分成治疗组 2 6例 ,奥美拉唑 2 0mg ,2次 /d ,阿莫西林 0 .5g ,3次 /d ,甲硝唑 0 .4g ,3次 /d。对照组 2 5例 ,奥美拉唑 2 0mg ,2次 /d。疗程 2周。疗程结束后 4周复查胃镜和HP。结果两组溃疡愈合率分别为 92 .3%和 88.0 % (P >0 .0 5 ) ,但HP根除率分别为 84.6%和 4.0 % (P <0 .0 5 )。治疗期间两组均有良好的耐受性。结论奥美拉唑加阿莫西林、甲硝唑治疗幽门螺杆菌阳性十二指肠溃疡有较高HP根除率 ,可作为临床治疗的优选方案之一  Objective  To study the omeprazole plus amoxicillin, metronidazole treatment of Helicobacter pylori-positive duodenal ulcer healing rate and HP eradication rate.  Methods  confirmed by gastroscopy, gastric mucosal biopsy confirmed HP infection with active duodenal ulcer 51 cases were randomly divided into treatment group 26 cases, omeprazole 20mg, 2 times / d, Amo Xilin 0 .5g, 3 times / d, metronidazole 0 .4g, 3 times / d. Control group 25 cases, omeprazole 20mg, 2 times / d. Treatment for 2 weeks. Gastroscope and HP were reviewed 4 weeks after the end of treatment. Results The healing rates of ulcer in both groups were 92.3% and 88.0% (P> 0.05), but the eradication rates of HP were 84.6% and 4.0%, respectively (P <0.05). Both groups were well tolerated during treatment.  Conclusion  omeprazole plus amoxicillin, metronidazole treatment of Helicobacter pylori-positive duodenal ulcer has a higher HP eradication rate, can be used as one of the preferred program of clinical treatment