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文献中曾有阿糖腺苷及其同类物单磷酸阿糖腺苷用于治疗慢性乙型肝炎有效的报导,但缺乏对照。本文报道用随机对照法对组织学证实的慢性乙型肝炎20例患者,应用单磷酸阿糖腺苷(Ara-AMP)治疗的研究结果。治疗组10例患者,在Ara-AMP的4周疗程中,DNA多聚酶活性下降到10%以下,其中5例在血清中不能检出。8例在治疗中DNA多聚酶始终阴性。一旦停药,除1例外,其它9例的血清DNA多聚酶水平又复升高。治疗期间,HBV-DNA可下降数倍,但除1例外,其余病例均可在血清中检出。停药后所有患者HBV-DNA水平均复升高。可见Ara-AMP治疗效
In the literature, there has been reported that adenosine monophosphate and its analogous adenosine monophosphate are effective in the treatment of chronic hepatitis B, but lack of control. This article reports the results of a randomized controlled trial of 20 patients with histologically confirmed chronic hepatitis B treated with Ara-AMP. In the 10 patients in the treatment group, DNA polymerase activity decreased to less than 10% during 4 weeks of Ara-AMP treatment, and 5 of them were undetectable in serum. 8 cases in the treatment of DNA polymerase is always negative. Once discontinued, with one exception, the other 9 cases of serum DNA polymerase levels again increased. During treatment, HBV-DNA can be decreased several fold, but with one exception, the remaining cases can be detected in serum. HBV-DNA levels in all patients recovered after withdrawal from treatment. Can be seen Ara-AMP treatment effect