论文部分内容阅读
我们于1985年引进食蟹猴疟原虫B株,观察其生物学特性,建成食蟹猴疟原虫B株——斯氏按蚊——恒河猴猴疟模型。B株原虫对斯氏按蚊感染性强,斯氏按蚊叮咬输血感染后7～11d的猴,其卵囊阳性率可达80～100％:第8d卵囊成熟,第10d子孢子进腺率平均52.7％.猴感染后第7d肝切片中红外期原虫不分叶,无空泡,内含无数排列整齐而粗大的核。用5×10~5个以上子孢子接种健康恒河猴的虫现前期为9～10d.本模型已初步应用于抗疟药复筛和疟疾免疫研究.
We introduced the C strain of malaria cynomolgus in 1985 to observe its biological characteristics and establish a malaria cercarie strain B - Anopheles stephensi-macaque malaria model. B strain of protozoan Anopheles sinensis infection is very strong, An. Sinensis bite blood transfusion 7 ~ 11d after the monkey, the positive rate of oocysts up to 80 to 100%: 8d oocysts mature, 10d sporozoites into the gland The average rate of 52.7% .7 weeks after infection, the monkey inoculation of the semi-infrared protozoa without leaves, no vacuoles, contains numerous arranged neat and coarse nuclei. Inoculation of healthy rhesus monkeys with more than 5 × 10 ~ 5 sporozoites was conducted for 9-10 days, and this model has been initially applied in rescreening of malaria drugs and malaria immunization.