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建立梗阻性黄疸模型，观察肠组织血小板活化因子（ＰＡＦ）含量变化与肠粘膜电位（ＰＤ）、肠组织磷酸脂酶Ａ２（ＰＬＡ２）活化、髓过氧化酶（ＭＰＯ）活力以及丙二醛（ＭＤＡ）含量的变化的关系。结果表明，梗阻性黄疸肠组织ＰＡＦ含量显著升高，与肠粘膜ＰＤ降低呈显著负相关（ｒ＝－０．９０，Ｐ＜０．０１）。提示ＰＡＦ是导致梗阻性黄疸肠粘膜屏障损害的重要因素之一，而ＰＬＡ２活化、中性粒细胞激活以及大量氧自由基释放是导致肠粘膜屏障损害的重要中间机制。
Obstructive jaundice model was established. The changes of PAF, PD, PLA2, MPO and malondialdehyde (MDA) in intestinal mucosa were observed. ) Content of the relationship between changes. The results showed that the content of PAF in intestinal tissue of obstructive jaundice increased significantly, which was negatively correlated with PD of intestinal mucosa (r = -0.90, P <0.01). These results suggest that PAF is one of the most important factors leading to intestinal mucosal barrier damage in obstructive jaundice. PLA2 activation, neutrophil activation and release of a large number of oxygen free radicals are important intermediate mechanisms leading to damage of intestinal mucosal barrier.