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完整的染色体末端之间以及与其它染色体的端粒之间没有发生联合的趋势,因为其游离末端被一种叫做端粒的物质所覆盖。然而在那些端部具有核仁组织者的正常染色体之间却可观察到端粒的联合。Yerganian等(1962)和Moorhead(1963)先后在SV-40感染的培养的人皮肤成纤维母细胞和长期体外培养的人胚胎纤维母细胞中观察到端粒-端粒(T-T)联合。这个不平常的现象也见于运动失调毛细血管扩张症患者,而这种病具有发展为淋巴瘤和其它恶性病的倾向。在肿瘤细胞,首先在小鼠骨髓瘤细胞中观察到了T-T联合。在人类,Fitzgera(1984)最先报告在早幼淋巴细胞性白血病和Burkitt型白血病中观察到了这种联合。
There is no tendency for association between intact chromosome ends and telomeres with other chromosomes because its free ends are covered by a substance called telomeres. However, the association of telomeres can be observed between the normal chromosomes of those with nucleolar organizers. Yerganian et al. (1962) and Moorhead (1963) have observed telomere-telomere (T-T) associations in SV-40 infected cultured human human skin fibroblasts and long-term cultured human embryonic fibroblasts. This unusual phenomenon is also seen in patients with dyskinetic telangiectasia, which has a tendency to develop lymphoma and other malignancies. In tumor cells, T-T association was first observed in mouse myeloma cells. In humans, Fitzgera (1984) first reported that this association was observed in prematurity lymphoblastic leukemia and Burkitt type leukemia.