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1966年Cohen等首先发现在X线照射前给小剂量粗制血卟啉衍生物(hematoporphyrin derivative简称HPD),可明显提高小鼠移植横纹肌肉瘤的疗效。1984
In 1966, Cohen et al. first discovered that giving a small dose of crude hematoporphyrin derivative (abbreviated HPD) before X-ray irradiation can significantly improve the efficacy of transplantation of rhabdomyosarcoma in mice. 1984