论文部分内容阅读
目的 探讨肝硬化患者凝血功能的变化及其与Child -Pugh肝功能分级的关系。方法 对 6 2例肝硬化患者 ,测定凝血酶原时间 (PT)、凝血酶时间 (TT)、纤维蛋白原 (FIB) ,并与 2 4例对照组比较 ,同时比较肝硬化不同Child -Pugh分级状态时PT、TT和FIB的差异。结果 肝硬化组与对照组比较 ,PT、TT明显延长 ,而FIB明显下降 ,其差异有显著性 (p <0 .0 1) ;按肝功能分级A→B→C顺序 ,显示PT、TT值逐渐延长 ,FIB值逐渐降低 ,差异均有显著性 (p <0 .0 1)。结论 肝硬化患者存在明显的凝血功能障碍 ,且随着肝功能损害程度的加重 ,其凝血障碍越明显
Objective To investigate the changes of coagulation function in patients with cirrhosis and its relationship with Child-Pugh classification of liver function. Methods Sixty patients with cirrhosis were enrolled in this study. Prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB) were measured and compared with 24 control subjects. Liver-cirrhosis and Child-Pugh scores Differences between PT, TT and FIB when in state. Results Compared with the control group, PT and TT were significantly increased in liver cirrhosis group and FIB was significantly decreased (P <0.01). According to the order of liver function classification A → B → C, the values of PT and TT Gradually extended, FIB values gradually decreased, the difference was significant (p <0. 01). Conclusion There is obvious coagulation dysfunction in patients with cirrhosis, and with the aggravation of liver damage, the more obvious coagulation disorder