醋酸棉酚治疗子宫肌瘤39例，同时以安宫黄体酮对照治疗14例。结果：总有效率醋酸棉酚组为87.18％，安宫黄体酮组为50％，两者差异显著（P＜0．01）。对15例应用棉酚者于用药前后测定血PRL、FSH、LH、E2、P，结果表明子宫肌瘤的缩小及其复发与FSH、LH、E2、P的变化有关，而与PRL关系不大，此项检测可用以判断疗效及预测是否复发。 Gossypol acetate treatment of 39 cases of uterine fibroids, while the control of ampoulerone progesterone treatment of 14 cases. Results: The total effective rate was 87.18% in the gossypol acetate group and 50% in the medroxyprogesterone group. The difference was significant (P<0.01). The PRL, FSH, LH, E2, and P in blood were measured before and after administration of 15 patients with gossypol. The results showed that the shrinkage and recurrence of uterine fibroids were related to the changes of FSH, LH, E2, and P, but not related to PRL. This test can be used to determine efficacy and predict recurrence.