绞股蓝总皂甙是从葫芦科植物绞股蓝[Gynostemma pentaphllam(Thunb) makin]中提得,具有镇静、催眠、抗疲劳、降血脂等功效。我们曾发现,能扩张冠状动脉,提高机体耐缺氧能力的药物,常可拮抗局部麻醉药的毒性,实验中观察到绞股蓝总皂甙,也能明显提高小鼠耐缺氧能力。本文报道绞股蓝总皂甙拮抗利多卡因毒性的实验观察。 Gynostemma total saponin is extracted from the Gynostemma pentaphllam (Thunb) makin, a cucurbitaceous plant, and has the effects of sedation, hypnosis, anti-fatigue and hypolipidemic effects. We have found that drugs that can dilate coronary arteries and improve the ability of the body to withstand hypoxia can often antagonize the toxicity of local anesthetics. Gypenosides have been observed in the experiment and can also significantly improve the ability of mice to withstand hypoxia. This article reports the experimental observation of gypenosides antagonizing the toxicity of lidocaine.