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目的观察动物对硅霜的毒理反应。方法家兔30只,随机均分为6组,观察硅霜对家兔完整及破损皮肤的急性毒性反应;家兔10只,随机均分为2组,观察硅霜对家兔完整及破损皮肤的刺激反应;小白鼠30只,随机均分为3组,观察硅霜对小白鼠的皮肤致敏反应。结果硅霜对家兔未出现任何急性毒性反应;家兔完整及破损皮肤无任何刺激性反应;小白鼠皮肤未见过敏反应。结论硅霜是一个安全无毒的外用药物。
Objective To observe the toxicological response of animals to silica frost. Methods Thirty rabbits were randomly divided into 6 groups to observe the acute toxicity of silicon cream on intact and damaged skin in rabbits. Ten rabbits were randomly divided into two groups to observe the effects of silicon cream on intact and damaged skin of rabbits. The stimuli response; 30 mice were randomly divided into 3 groups to observe the skin sensitization response of silicon cream to mice. Results There was no acute toxic reaction of silicon cream on rabbits; intact and damaged skin of rabbits did not have any irritative reaction; no allergic reaction was observed on mice skin. Conclusion Silicon cream is a safe and non-toxic topical medicine.