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从野梧桐Mallotus japonicus Muell.Arg.果皮的氯仿提取物中分离到7个间苯三酚衍生物(1～7)以及由(1)衍生的2个间苯三酚(8～9),经体外筛选证实均有较强的抗促癌活性,其50μg/ml可100％抑制促癌剂TPA强化的~3H-胆碱与C3H10T1/2细胞磷脂的结合。过去曾报道了这些化合物对KB细胞的细胞毒性,尤以化合物(1)显示强的细胞
Seven phloroglucinol derivatives (1-7) and two phloroglucinol (8-9) derived from (1) were isolated from the chloroform extract of the pericarp of Mallotus japonicus Muell. Arg. In vitro screening confirmed strong anti-cancer activity, 50μg / ml 100% inhibition of promoting agent TPA-enhanced 3H-choline and C3H10T1 / 2 cell phospholipid binding. The cytotoxicity of these compounds on KB cells has been reported in the past, especially when compound (1) shows strong cells