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Shh信号对于神经系统的发育、分化以及神经系统肿瘤的发生都起着十分重要的诱导作用。近年来对于Shh信号在神经系统作用的研究已不断深入,包括诱导胚胎中脑、菱脑节、端脑、脊髓、视神经的发育;促进成体胼胝体和大脑皮层细胞的增殖;诱导神经系统肿瘤的发生等。这一系列生理及病理变化十分复杂,有多因素的参与,而Shh信号起着重要的角色。因此弄清Shh信号路径对神经系统的作用,必然对神经干细胞移植以及神经系统恶性肿瘤的治疗起着一定的指导作用。
Shh signaling plays a very important role in the development of the nervous system, differentiation and the occurrence of nervous system tumors. In recent years, the research on the role of Shh signal in the nervous system has been deepened, including the induction of the embryonic midbrain, rhomb brain node, telencephalon, spinal cord, optic nerve development; promote the proliferation of adult corpus callosum and cortex cells; induce the nervous system tumors Wait. This series of physiological and pathological changes is very complex and involves many factors, and Shh signaling plays an important role. Therefore, clarifying the role of Shh signaling pathway in the nervous system is bound to play a guiding role in neural stem cell transplantation and the treatment of neurological malignancies.