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研究证实缺血集聚产生组织损伤是通过缺血坏死和凋亡两条途径。脑缺血后需要确定凋亡受累基因。用阻滞凋亡细胞死亡制剂可以作为治疗急性缺血性卒中的另一途径。近期,基因转移至体外和活体内的颈动脉颅内血管已获得成功,可用于预防蛛网膜下腔出血后的血管痉挛,刺激侧支血管生长,稳定粥样硬化斑块和预防血管成形术后的再狭窄。基因转移也可治疗因细胞激酶抑制或过度表达和神经细胞作用下的缺血。
Studies have confirmed that ischemia-induced tissue damage caused by ischemic necrosis and apoptosis are two ways. It is necessary to determine the genes involved in apoptosis after cerebral ischemia. Apoptotic cell death preparations can be used as another way to treat acute ischemic stroke. Recently, gene transfer into the intracranial arteries of the carotid arteries in vitro and in vivo has been successful and may be used to prevent vasospasm following subarachnoid hemorrhage, stimulate collateral vessel growth, stabilize atherosclerotic plaques, and prevent angioplasty Restenosis. Gene transfer can also be used to treat ischemia or ischaemia due to inhibition or overexpression of cellular kinases.