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【目的】探讨腔内治疗合并糖尿病的周围动脉闭塞性病变（Peripheral Arterial Occlusive Disease ， PAOD）的疗效。【方法】回顾性分析35例伴发糖尿病的PAOD患者48次腔内治疗的临床资料。【结果】腔内操作技术成功率97．1％，术后30 d无死亡病例。术前踝肱指数（0．419±0．142）显著低于术后（0．741±0．158），其差异有统计学意义（ P ＜0．01）；6个月、12个月、24个月及36个月的初次通畅率分别为85．2％、61．9％、54．3％及46．2％，二次通畅率分别为91．5％、83．1％、70．2％及63．3％，肢体保存率分别为94．3％、88．6％、85．8％及82．9％。【结论】经皮腔内治疗糖尿病PAOD具有通畅率较高、并发症少的优点，能较好地保持患肢的完整性。“,”[Objective]To explore the efficacy of endoluminal therapy for diabetes mellitus with peripheral arterial occlusive disease(PAOD) .[Methods]Clinical data of 35 PAOD patients with diabetes mellitus treated by endoluminal therapy for 48 times were analyzed retrospectively .[Results] Endoluminal operation success rate was 97 .1% 34/35) .No one died 30d after operation .Ankle/brachial index before operation was (0 .419 ± 0 .142) which was markedly higher than that after operation (0 .741 ± 0 .158) ,and there was significant difference( P < 0 .001) .Primary patency rate at 6 months ,12 months ,24 months and 36 months was 85 .2% ,61 .9% ,54 .3% ,and 46 .2% respectively ,and .secondary patency rate was 91 .5% ,83 .1% ,70 .2%and 63 .3% respectively ,and limb preservation rate was 94 .3% ,88 .6% ,85 .8% and 82 .9% ,respectively .[Conclusion] Percutaneous endoluminal therapy for diabetic patients with PAOD has advantages such high pa-tency and few complications ,and can better remain the integrity of the affected limbs .