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用微量稀释法比较了氧氟沙星、环丙沙星等喹诺酮化合物及大环内酯、四环素类抗生素体外抗枝原体活性，结果显示：对于解脲尿枝原体（Ｕｕ）、人型枝原体（Ｍｈ）、口腔枝原体（Ｍｏｒａ）和唾液枝原体（Ｍｓａｌ），喹诺酮类药物有中等抑制活性：氧氟沙星＞环丙沙星＞诺氟沙星＞萘啶酸；枝原体对大环内酯类抗生素高度敏感，其中交沙霉素活性最强，对Ｕｕ、Ｍｈ、Ｍｏｒａ、Ｍｓａｌ的ＭＩＣ分别为０．１２５、０．１２５、０．００７８和０．０１５６ｍｇ／Ｌ；四环素类抗生素中多西环素活性又大于四环素，对上述４种枝原体的ＭＩＣ分别是四环素的１／２～１／８倍。Ｕｕ、Ｍｈ对四环素和１４元大环内酯类抗生素红霉素易产生耐药性，对１６元大环内酯类抗生素交沙霉素、吉他霉素、泰洛星及喹诺酮类药物则相对不易产生耐药性。但对Ｍｈ，经喹诺酮类药物１０次诱导，ＭＩＣ增大８倍，呈现一定的耐药性。Ｕｕ、Ｍｈ的四环素或红霉素耐药株对红霉素或四环素有交叉耐药性，而对喹诺酮类药物、１６元大环内酯类抗生素则无交叉耐药性
The microdilution method was used to compare the activity of quinolone compounds such as ofloxacin and ciprofloxacin, macrolide and tetracycline antibiotics against mycoplasma in vitro. The results showed that for Uu, ureaplasma urealyticum Mh, Mora, and Msal, and quinolones showed moderate inhibitory activity: ofloxacin> ciprofloxacin> norfloxacin> nalidixic acid; Mycoplasma highly sensitive to macrolide antibiotics, of which josamycin the strongest, MIC of Uu, Mh, Mora, Msal were 0.125,0.125,0.0078 and 0.0156mg / L; the activity of doxycycline in tetracycline antibiotics is greater than that in tetracycline; the MIC of the four mycoplasmas is 1-2 times of tetracycline, respectively. Uu and Mh are susceptible to tetracycline and 14-membered macrolide antibiotics erythromycin, while 16-membered macrolide antibiotics jasminemycin, tylosin, tylosin and quinolones are relatively Not easy to produce resistance. However, Mh, quinolones induced by 10 times, MIC increased by 8 times, showing some resistance. Uu, Mh tetracycline or erythromycin resistant strains of erythromycin or tetracycline have cross-resistance, and quinolones, 16 macrolide antibiotics are not cross-resistant