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循环中游离DNA是各种原因引起组织破坏时释放出来的。正常人循环中DNA水平很低(25ng/ml以下),可能由于释放速率低,或因其在脱氧核酸酶(DNAse)的作用下迅速降解。在某些病理状态下,如系统性红斑狼疮、类风湿性关节炎、肺栓塞和恶性肿瘤时,可能由于DEAse的活性受到抑制,DNA在血循环中蓄积,故血清中DNA水平升高。为验证上述理论,作者对398例胃肠道疾病患者进行了研究。患者有下列一个或数个主要症状:腹痛、进行性体重减轻、黄疸和直肠出血。经体检、常规化验、胆道造影、钡餐、CT、超声、活检或剖腹探查以及DNA水平测定等一系列检验后,386例(包括恶性肿瘤)得到确诊。其余12例因
Free DNA in the circulation is released when the tissue is destroyed by various causes. The DNA level in normal human circulation is very low (25 ng/ml or less), probably due to a low release rate, or because of its rapid degradation under the action of DNAse. In certain pathological conditions, such as systemic lupus erythematosus, rheumatoid arthritis, pulmonary embolism, and malignancy, DNA may be accumulated in the blood circulation due to the inhibition of DEAse activity, and thus the level of DNA in the serum is increased. To verify the above theory, the authors studied 398 patients with gastrointestinal disorders. The patient has one or more of the following major symptoms: abdominal pain, progressive weight loss, jaundice, and rectal bleeding. After a series of tests including physical examination, routine laboratory tests, cholangiography, barium meal, CT, ultrasound, biopsy or laparotomy, and DNA level determination, 386 cases (including malignant tumors) were confirmed. The remaining 12 cases