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1964年9～10月杭州××幼儿园有32例儿童在临床上表现为无菌性脑膜炎、上感及腹泻型和6例为健康接触者的38份粪便中分离出病毒14株,经鉴定为柯萨奇 B_3型病毒12株,脊髓灰质炎Ⅱ型病毒及未定型者各1株。另自1例无菌性脑膜炎的脑有液中亦分离到1株柯萨奇 B_3型病毒。在16例双份血清中,有12例血清对柯萨奇 B_3型病毒中和抗体滴度有4倍或4倍以上升高;8例恢复期血清中,有4例血清抗体滴度高达≥1∶128。从而经病毒分离及双份血清抗体测定证实系柯萨奇 B_3型病毒感染引起的一次小型暴发。
From September to October 1964, 32 children in Hangzhou × × kindergarten were clinically aseptic meningitis, 14 were isolated from 38 faeces of upper respiratory tract and diarrhea type and 6 healthy persons. 12 strains of Coxsackie virus B_3, 1 strain of poliovirus type 2 and 1 strain of undeclared ones. Another case of aseptic meningitis in brain fluid also isolated a Coxsackie B_3 virus. Of the 16 double serum samples, 12 had a 4-fold or 4-fold increase in the titer of the neutralizing antibody against Coxsackie virus B_3, and 4 of the 8 serum samples recovered during the convalescent phase had a titer of> 1:128. Thus, a small outbreak caused by Coxsackie B_3 virus infection was confirmed by virus isolation and double serum antibody assay.