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趋钙激素(Calcitrophic Hormone)有三种:甲状旁腺素(PTH),VitD 及降钙素(Calc-itonin),成年人体钙稳态的维持主要受前两种激素控制。PTH 和/或 VitD 的合成分泌以及特异性靶器官对激素的反应异常均可导致钙平衡紊乱。本文主要从受体——效应系统论述 PTH 和 VitD 异常所引起的临床紊乱。一、分子生物学概况(一)PTH1.生物化学机制:PTH 与共他肽类及单胺类生物活性物质一样,须由细胞膜受体——腺苷酸环化酶复合物介导,才能完成其生化效应。此复合物包括三种结构蛋日质:①细胞膜外层表面的特异性受体;②位于细胞膜内侧、能将 ATP—Mg~(2+)转变为 cAMP 的催化单位;③乌嘌呤核苷酸结合单位(G 单位)。PTH 首先引发特异性受体与 G 单
There are three types of Calcitrophic Hormone: PTH, VitD and Calc-itonin. The maintenance of calcium homeostasis in adults is mainly controlled by the first two hormones. The combined secretion of PTH and / or VitD and the abnormal response of specific target organs to hormones can lead to calcium balance disorders. This article discusses the clinical disorders caused by PTH and VitD abnormalities mainly from the receptor-response system. First, the general situation of molecular biology (a) PTH1. Biochemical mechanism: PTH and co-tocotrienols and monoamine bioactive substances, to be mediated by the cell membrane receptor - adenylate cyclase complex in order to complete its Biochemical effects. The complex includes three types of egg quality: ① specific receptors on the outer surface of the cell membrane; ② catalytic units that convert ATP-Mg ~ (2+) to cAMP on the inner side of the cell membrane; and ③ purine nucleotides Binding unit (G unit). PTH first elicits specific receptors and G single