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目的:探讨急性脑梗死患者血清神经元特异性烯醇化酶(NSE)与谷胱甘肽-S-转移酶(GST)的含量及临床意义。方法:入选的32例急性脑梗死患者为我院2007-01/2009-06住院患者,作为观察组,另选同期32例健康体检者作为对照组,分别采用放免法和ELISA法检测两组的血清NSE与GST的含量。结果:观察组发病3d内血清NSE显著升高,2周后复查明显降低,而血清GST发病3d明显低于正常对照组,2周后复查明显升高,且高于正常对照组。二者相关分析显示呈负相关(r=-0.143,P<0.05)。结论:通过检测不同发病时间急性脑梗塞患者的的NSE及GST含量,可以为急性脑梗塞发病的病情、临床治疗及预后提供一定的指导依据。
Objective: To investigate the content and clinical significance of serum neuron specific enolase (NSE) and glutathione S-transferase (GST) in patients with acute cerebral infarction. Methods: Thirty-two patients with acute cerebral infarction were selected as hospitalized patients in our hospital from January 2007 to June 2009 as the observation group and another 32 healthy subjects as the control group. The patients in the two groups were treated with radioimmunoassay and ELISA respectively Serum NSE and GST content. Results: In the observation group, serum NSE was significantly increased within 3 days of onset and decreased significantly after 2 weeks. However, the serum GST level was significantly lower than that of the normal control group 3d and significantly higher after 2 weeks, which was higher than that of the normal control group. The correlation analysis showed a negative correlation (r = -0.143, P <0.05). Conclusion: The detection of NSE and GST levels in patients with acute cerebral infarction at different stages of onset may provide some guidance for the treatment of acute cerebral infarction and its prognosis.