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目的:观察高血压患者在降压治疗的同时应用阿托伐他汀联合阿司匹林消退颈动脉粥样斑块的疗效。方法:将高血压合并不同程度颈动脉粥样硬化斑块患者78例随机分为治疗组(46例)和对照组(32例),治疗组患者除服用降高血压药物外,每晚给予阿托伐他汀20mg+阿司匹林100mg;对照组仅服用降高血压药物进行降压治疗。分别于6个月及12个月后观察疗效。结果:治疗组服药6个月后斑块消失率达20.5%;服药12个月后消失率达34.2%;未消失的斑块面积均有不同程度的缩小。对照组颈动脉硬化斑块共有48个,6个月后斑块增加3个,增加7%;12个月后斑块增加7个,增加15%。2组比较差异有统计学意义(P<0.05)。结论:高血压患者在降压的同时服用阿托伐他汀和阿司匹林,对颈动脉硬化斑块的消退及稳定有明显疗效。
Objective: To observe the curative effect of atorvastatin combined with aspirin on the relief of carotid artery atherosclerotic plaque in patients with hypertension. Methods: Seventy-eight patients with hypertension and carotid atherosclerosis plaque were randomly divided into treatment group (46 cases) and control group (32 cases). Patients in treatment group were treated with antihypertensive drugs every night Atorvastatin 20mg + aspirin 100mg; control group only taking antihypertensive drugs for antihypertensive treatment. The efficacy was observed after 6 months and 12 months respectively. Results: The disappearance rate of plaque in treatment group reached 20.5% after 6 months. The disappearance rate reached 34.2% in 12 months after treatment. The extent of non-disappeared plaque was reduced to some extent. There were 48 carotid atherosclerotic plaques in the control group. After 6 months plaque increased by 3, an increase of 7%. After 12 months, plaque increased by 7, an increase of 15%. The difference between the two groups was statistically significant (P <0.05). Conclusions: Hypertensive patients taking atorvastatin and aspirin at the same time with antihypertensive treatment have obvious curative effect on the regression and stability of carotid plaque.