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目的探讨环孢菌素A联合十一酸睾酮治疗慢性再生障碍性贫血(CAA)疗效及不良反应。方法环孢菌素A(CsA)5mg/(kg.d)联合十一酸睾酮40mgtid治疗CAA28例,同期单用十一酸睾酮40mgtid治疗的CAA20例作为对照组。按全国统一标准评定疗效。结果联合治疗组28例,基本治愈5例,缓解10例,明显进步7例,无效6例,总有效率78.57%;对照组20例,基本治愈2例,缓解4例,明显进步4例,无效10例,总有效率50%。两组有效率比较P<0.01,有统计学差异,治疗组疗效高于对照组。治疗组有效病例起效中位时间为120天,对照组有效病例起效中位时间为150天。治疗过程中药物不良反应少。结论CsA+十一酸睾酮治疗CAA疗效高于单用十一酸睾酮治疗组,而且起效快,不良反应少,大多数病人均能接受治疗。
Objective To investigate the efficacy and adverse reactions of cyclosporin A combined with testosterone undecanoate in the treatment of chronic aplastic anemia (CAA). Methods 28 cases of CAA were treated with cyclosporine A (CsA) 5mg / (kg · d) combined with testosterone undecanoate 40mgtid and 20 cases of CAA treated with testosterone 40mgtid alone in the same period as the control group. According to a unified national standard assessment of efficacy. Results In the combined treatment group, 28 cases were cured basically, 5 cases were basically cured, 10 cases were relieved, 7 cases were significantly improved, 6 cases were ineffective and the total effective rate was 78.57%. In the control group, 20 cases were basically cured, 4 cases were alleviated, 4 cases were significantly improved, Invalid 10 cases, the total efficiency of 50%. Efficacy of the two groups compared P <0.01, with statistical differences, the treatment group than the control group. The effective time of the treatment group was 120 days, and the effective time of the control group was 150 days. Adverse drug reactions in the course of treatment less. Conclusions CsA + testosterone undecanoate is more effective than testosterone undecanoate alone in the treatment of CAA. It has fast onset of action and few adverse reactions. Most patients receive treatment.