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碱性或酸性成纤维细胞生长因子(bFGF或aFGF)是两种关系密切、作用于共同受体的生长因子。两者对众多源于中胚层及神经外胚层的细胞具有相似的生物功能,起形态发生因子和促有丝分裂素的作用。另外,bFGF可作为一种腹植化因子(ventovegetalizing factor),后者能在中囊胚期诱导原本形成外胚层的动物极细胞(pole cells)形成中胚层结构。这一作用可解释为何在胚胎后期、新生儿期乃至成年期,机体有众多组织细胞包括中枢、周围神经系统与血管系统等均受FGF的影响。
Alkaline or acidic fibroblast growth factor (bFGF or aFGF) are two closely related growth factors that act on a common receptor. Both have similar biological functions to many cells derived from mesoderm and neuroectoderm and function as morphogenic factors and mitogens. In addition, bFGF can be used as a ventovegetalizing factor that induces mesoderm structure in the pole cells that originally formed ectoderm. This effect may explain why in the late embryonic, neonatal, and even adult stages, many tissues of the body including the central nervous system, peripheral nervous system, and vascular system are affected by FGF.