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目的观察脑梗死患者颈动脉粥样硬化斑块与血浆白介素-6(IL-6)、脂蛋白(a)[Lp(a)]及纤维蛋白原(Fib)水平的关系。方法对60例脑梗死患者行颈动脉超声检查,以发现颈动脉粥样硬化斑块并确定性质。检测脑梗死患者和30例健康体检者的血浆IL-6、Lp(a)、和Fib水平。结果44例(73.3%)脑梗死患者有颈动脉斑块,16例(26.7%)无斑块;其中易损斑块27例(45%),非易损斑块17例(28.3%)。脑梗死患者的血浆Fib水平均显著高于正常对照组(P均<0.05);易损斑块组的IL-6、Lp(a)水平显著高于非易损斑块组及正常对照组。IL-6与Lp(a)、Fib水平呈正相关(P均<0.05)。结论血浆IL-6、Lp(a)与颈动脉粥样硬化易损斑块并发的脑梗死有关;血浆高Fib水平可促进脑梗死的发生。
Objective To investigate the relationship between the levels of interleukin-6 (IL-6), lipoprotein (a) [Lp (a)] and fibrinogen (Fib) in patients with cerebral infarction. Methods 60 patients with cerebral infarction underwent carotid ultrasonography to detect carotid atherosclerotic plaques and determine the nature. Plasma IL-6, Lp (a), and Fib levels were measured in patients with cerebral infarction and in 30 healthy subjects. Results Forty-four patients (73.3%) had carotid artery plaque and 16 (26.7%) had no plaque. Among them, 27 (45%) were vulnerable plaque and 17 (28.3%) non-vulnerable plaque. The levels of plasma Fib in patients with cerebral infarction were significantly higher than those in normal control group (all P <0.05). The levels of IL-6 and Lp (a) in vulnerable plaque group were significantly higher than those in non-vulnerable plaque group and normal control group. There was a positive correlation between IL-6 and Lp (a) and Fib levels (all P <0.05). Conclusions Plasma IL-6 and Lp (a) are associated with cerebral infarction complicated with carotid atherosclerotic vulnerable plaque. High plasma Fib levels may promote cerebral infarction.