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对509例门诊查体者进行了ALT及HAV、HBV、HCV、HDV、HEV标志物的检测;并对检测出的肝炎病毒感染者、肝炎患者以及肝炎病毒标志物阴性者(对照组)的血液进行了SOD、GSH-PX、LPO测定。结果显示:肝炎病毒感染者、肝炎患者血中SOD、GSH-PX的含量,均显著低于对照组(P<005);LPO的含量高于对照组(P<005,P<001),当多种肝炎病毒混合感染时血SOD、GSH-PX下降、LPO增高更明显,其中以HBV、HCV、HEV三重叠感染及复合型肝炎(HBV、HCV、HDV)时更为显著(P<005),提示:肝炎病毒感染者及肝炎患者血SOD、GSH-PX均有不同程度降低,LPO却有不同程度增高,并与肝损伤有一定的相关性。
The detection of ALT, HAV, HBV, HCV, HDV and HEV markers in 509 outpatients was carried out. The blood samples from hepatitis B virus infected patients, hepatitis patients and hepatitis B virus negative samples (control group) SOD, GSH-PX and LPO were measured. The results showed that the contents of SOD and GSH-PX in the blood of hepatitis virus infected patients and hepatitis patients were significantly lower than those of the control group (P <005), and the content of LPO was higher than that of the control group (P <005, P < 001), when a variety of hepatitis B virus mixed infection, blood SOD, GSH-PX decreased, LPO increased more significantly, including HBV, HCV, HEV triple overlapping infection and hepatitis B (HBV, HCV, HDV) (P <005), suggesting that the serum levels of SOD and GSH-PX in patients with hepatitis B virus infection and hepatitis were decreased to varying degrees, while LPO increased to some extent and had certain correlation with liver injury.