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目的:研究谷氨酰胺对重症胰腺炎的免疫功能的影响。方法:40例重症胰腺炎患者随机分成试验组和对照组,各20例。2组患者均行肠外营养,连续7d,其中试验组静脉应用力肽0.4g.(kg.d)-1。2组治疗前和治疗后7d抽取外周血测量血清总蛋白(TP)、白蛋白(ALB)、转铁蛋白(TF)以及外周血T淋巴细胞亚群CD3+、CD4+、CD4+/CD8+所占比例。结果:2组患者治疗后免疫指标均有不同程度的升高,其中研究组TF、CD3+、CD4+和CD4+/CD8+所占比例升高均较对照组明显(P<0.05)。结论:谷氨酰胺增强的免疫营养能提高重症胰腺炎患者机体免疫功能,减轻病情的危重程度,改善预后。
Objective: To study the effect of glutamine on immune function of severe acute pancreatitis. Methods: Forty patients with severe pancreatitis were randomly divided into experimental group and control group, with 20 cases each. The patients in both groups were given parenteral nutrition for 7 consecutive days, in which the test group received 0.4 g · kg -1 of peptide (peripheral blood serum) before and after 7 d of treatment for determination of serum total protein (TP), white (ALB), transferrin (TF) and peripheral blood T lymphocyte subsets CD3 +, CD4 +, CD4 + / CD8 + ratio. Results: The immunological indexes of the two groups increased to some extent after treatment. The proportion of TF, CD3 +, CD4 + and CD4 + / CD8 in the study group was significantly higher than that in the control group (P <0.05). CONCLUSION: Glutamine-enhanced immune nutrition can improve the immune function of patients with severe pancreatitis, reduce the severity of the disease and improve the prognosis.