目的 :寻找明党参产地加工时引起过敏反应的物质。方法 :根据产地加工明党参过程中可能接触过敏物质的方式 ,以豚鼠皮肤涂敷和雾化接触两种方式 ,分别给予鲜明党参自然挥发性顶空气体组分A、沸水烫挥发性顶空气体组分B、挥发油和蛋白质 ,进行过敏试验 ,观察皮肤过敏反应 ,评价致敏程度。结果 :鲜明党参中提得的挥发油在两种给药途径下 ,均可使豚鼠产生过敏反应。结论 :挥发油为明党参中的致敏物质。 Objective : To search for substances that cause allergic reactions during processing of the production of Radix Codonopsis. METHODS: According to the method of processing allergic substances in the production process of Codonopsis pilosula, the guinea pig skin and atomized contact methods were used to give the natural volatile components of Radix Codonopsus to the top of the air component A and the boiling hot volatility top air body. Component B, volatile oil and protein, allergy test, observed skin allergies, and assess the degree of sensitization. Results: The volatile oil extracted from Radix Codonopsitis can induce allergic reactions in guinea pigs under both routes of administration. Conclusion : Volatile oil is a sensitizing substance in D. smyrnioides.