一些病原微生物在宿主细胞内寄生甚至生长繁殖,此类病原微生物可免受宿主体液免疫力和细胞外抗菌药物的杀伤,临床上往往出现抗菌药物治疗失败、病情复发、感染慢性化或呈迁延性。病原微生物、吞噬细胞和抗菌药物三者之间的关系错综复杂,本文就近几年有关抗菌药物对胞内病原微生物作用的研究综述如下。 Some pathogenic microorganisms in the host cell parasitization or even growth and reproduction, such pathogenic microorganisms from the host humoral immunity and anti-bacterial anti-bacterial drugs, the clinical treatment of antibiotics often appear failure, relapse, chronic infection or persistent . The relationship between pathogenic microorganisms, phagocytes and antimicrobial agents are complex. In this paper, the recent studies on the effect of antimicrobial agents on intracellular pathogenic microorganisms are summarized as follows.