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对抗癫痫药物的血清或血浆浓度的监测已列为常规,苯妥因钠的剂量与血清浓度之间无线性关系,而剂量与神经中毒(嗜睡、共济失调、构音障碍、眼球震颤)有关,因而治疗范围狭窄,为避免长期癫痫发作的病人发生神经中毒,有必要进行血药浓度监测,苯妥因钠的治疗范围概念已扩大到其它抗癫痫药物,目前很多实验室的常规测试除了苯妥因钠外还尚有对其它药物血清浓度的测试,这是一个有疑问的做法.
Monitoring of sera or plasma concentrations of anti-epileptic drugs has been routinely observed. There is no linear relationship between the dose of phenytoin sodium and serum concentration, and the dose is associated with neurotoxicity (drowsiness, ataxia, dysarthria, nystagmus) , So the scope of treatment is narrow, in order to avoid long-term seizures in patients with neurotoxicity, the need for blood concentration monitoring, the concept of treatment of phenytoin sodium has been extended to other antiepileptic drugs, many laboratories routine tests except benzene It is doubtful that proper serum concentrations of other drugs should be tested outside of sodium.