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放射性金属包裹于脂质体中可用于肿瘤造影。本文确定了肿瘤造影用的脂质体组成,并用以鉴别肿瘤和炎症。实验用Ehrlish实体瘤和Yoshida肉瘤作肿瘤模型,用角叉菜胶引起肉芽组织产生炎症。将~(67)Ga-NTA、~(67)Ga-EDTA、~(51)Cr-NTA、~(67)Cr-EDTA分别包入脂质体中,静脉注射后比较它们在肿瘤中的放射活性。结果肿瘤对~(67)Ga-NTA-脂质体的摄取量最大。直径60nm的小单层脂粒(SUVs)输送~(67)Ga至
Radioactive metal encapsulated in liposomes can be used for tumor imaging. This article identifies the composition of liposomes used for tumor imaging and is used to identify tumors and inflammation. Experimental Ehrlish solid tumors and Yoshida sarcoma were used as tumor models to induce inflammation in granulation tissue with carrageenan. The ~(67)Ga-NTA,~(67)Ga-EDTA,~(51)Cr-NTA,~(67)Cr-EDTA were encapsulated into liposomes, and their radioactivity was compared after intravenous injection. active. Results Tumors had the highest uptake of ~(67)Ga-NTA-liposomes. 60nm diameter small monolayers (SUVs) deliver ~(67) Ga to