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本文讨论了实验性缺氧对大鼠凝血机能产生的影响。实验结果表明,大鼠在模拟8000米高度两小时后,血小板凝聚性、血小板因子3活性明显增加,纤溶活性下降,同时,纤维蛋白原含量和因子X也明显下降。大鼠在模拟7000米经36天间歇性慢性缺氧,血小板计数、血小板凝聚性,血小板因子3活性、纤维蛋白原含量、因子X活性均显著增加,部分凝血活酶时间缩短、纤溶活性下降,明显地出现凝血增强的趋势。本文还讨论了抗缺氧药物复方党参、异叶青兰对人鼠急性缺氧时凝血机能的影响。
This article discusses the effects of experimental hypoxia on the coagulation function in rats. The experimental results showed that after simulating the height of 8000 meters for two hours, the platelet cohesion, platelet factor 3 activity and the fibrinolytic activity decreased obviously. At the same time, the content of fibrinogen and the factor X decreased obviously. Rats in the simulated 7 000 m after 36 days of intermittent chronic hypoxia, platelet count, platelet aggregation, platelet factor 3 activity, fibrinogen content, factor X activity were significantly increased, partial thromboplastin time shortening, fibrinolytic activity decreased , There is clearly a tendency of coagulation enhancement. This article also discussed the anti-hypoxia drug compound Codonopsis, Isoelanda different human acute hypoxia clotting function.