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赘生性心内膜炎是全人工心脏动物的一个致命的并发症。本文分析美国犹他大学人工器官研究所在1980—1983四年间,114例全人工心脏动物中46例(40,35％)合并赘生性心内膜炎的临床表现、尸检所见及治疗经过。诊断标准为人工心脏中有赘生物,及血培养或心内培养有阳性或伴有明显感染症状者。感染多来源于驱动管道的感染,术中或术后污染及动物的自身感染,最常见的致病菌为绿脓杆菌。动物的死亡原因及尸检所见多系与赘生物有关的感染,充血性心力衰竭及人工心脏的机械故障。赘血物常见于输入瓣膜区。其发病机制与人工心脏的异物,血液流态,凝血机制及感染有密切关系。主要预防方法为改进人工心脏的设计与制作,提高材料的生物相容性,合宜的抗凝治疗,以及严格的无菌技术。药物治疗只能延缓病程,外科手术可能有所裨益。对全人工心脏赘生性心内膜炎的研究,将有助于全人工心脏在临床上的成功应用。
Neoplasm Endocarditis is a fatal complication of whole heart cardiac animals. This article analyzes the clinical manifestations of 46 cases (40,35%) of 114 total artificial heart animals with neoplasm endocarditis in the United States Utah University Institute of Artificial Organ in the 1980-1983 four years, autopsy findings and treatment through. Diagnostic criteria for artificial heart in vegetation, and blood culture or intracardiac positive or with significant symptoms of infection. Mostly from the infection-driven infection in the pipeline, intraoperative or postoperative pollution and animal infection, the most common pathogen Pseudomonas aeruginosa. Causes of death of animals and autopsy seen more lines and neoplasms related infections, congestive heart failure and mechanical heart failure. Infiltration of blood is common in the valve area. Its pathogenesis and artificial heart foreign body, blood flow, coagulation mechanism and infection are closely related. The main prevention method is to improve the design and manufacture of artificial heart, improve the biocompatibility of materials, appropriate anticoagulant therapy, and strict aseptic technique. Medication can only slow the course of the disease, and surgery may be helpful. The study of all artificial heart neoplasm endocarditis, will help the successful application of all artificial heart in the clinic.