血管内皮细胞既可通过合成分泌PGI_2、血栓调节蛋白(Thrombo-modulin)、t-PA等起抗血栓作用,又能通过合成分泌vWF、PAI等起促血栓形成的作用。因此,血管内皮细胞在止血血栓中的作用越来越受到人们注意,血管内皮细胞研究已成为止血血栓研究的重要方面。PGI_2是由内皮细胞合成的一种强的血管扩张剂和血小板聚集抑制物质,与TXA_2的作用相反。PGI_2与TXA_2之间活性的平衡是控制正常止血机制、防治血栓形 Vascular endothelial cells play the role of thrombosis through the synthesis and secretion of PGI_2, Thrombo-modulin, t-PA and other anti-thrombotic effects, as well as the synthesis and secretion of vWF and PAI. Therefore, the role of vascular endothelial cells in hemostatic thrombosis more and more attention, vascular endothelial cell research has become an important aspect of the study of hemostatic thrombosis. PGI_2 is a strong vasodilator and platelet aggregation inhibitor synthesized by endothelial cells, which has the opposite effect of TXA_2. The balance of activity between PGI_2 and TXA_2 is to control the normal hemostatic mechanism and prevent thrombosis