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心得安是1960年合成的强力β-受体阻断药,1964年始用于临床。目前广泛用于抗心绞痛、抗心律失常、抗高血压等,并取得较好的临床效果。但是亦在不同程度上存在着滥用现象,为了提高临床疗效,减少毒性副作用,有必要对其药物代谢的规律和药理作用特点,临床使用适应证等问题加以介绍。心得安临床药理特点:心得安化学结构中的基本母核具有选择性对抗β-受体作用,能竞争性地与β-受体结合,从而对抗介质和拟肾上腺素药物的β-受体作用,表现出强力的β-受体阻断作用。心得安对心脏的β-受体和血管、支气管平滑肌的β_2-受体均有阻断作用,
Adventurous is a potent β-blocker synthesized in 1960 and was used clinically in 1964. Currently widely used in anti-angina, anti-arrhythmia, anti-hypertension, and achieved better clinical results. However, there are also abuse to varying degrees. In order to improve the clinical curative effect and reduce the toxic side effects, it is necessary to introduce the characteristics of drug metabolism, pharmacological effects and clinical indications. Adventurous clinical pharmacological characteristics: Adams Ann chemical structure of the basic mother nucleus selective antagonism of β-receptor, can be competitive with the β-receptor, thus antagonizing the media and adrenergic drugs β-receptor , Showing potent β-receptor blockade. Pro-heart on the β-receptors and blood vessels, bronchial smooth muscle β 2-receptor blockade,