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目的观察帕米磷酸二钠治疗恶性肿瘤骨转移及多发性骨髓瘤骨痛的临床疗效及毒副反应。方法分别对19例恶性肿瘤骨转移及6例多发性骨髓瘤骨痛患者采用帕米磷酸二钠60 mg加5%葡萄糖静滴4 h以上,每月1~2次,3个月为1个疗程。结果25例恶性肿瘤骨转移及多发性骨髓瘤患者骨痛都不同程度的得到减轻,除1例静滴时出现发冷给予5 mg地塞米松处理其余24例无明显不良反应。结论帕米磷酸二钠作为双磷酸盐类药物之一,在对晚期肿瘤骨转移及多发性骨髓瘤引起的骨痛治疗安全有效。
Objective To observe the clinical efficacy and toxicity of pamidronate disodium in the treatment of bone metastases of malignant tumors and multiple myeloma bone pain. Methods Nineteen patients with bone metastases of malignant tumors and 6 patients with multiple myeloma and bone pain were treated with Pamidronate disodium 60 mg plus 5% glucose intravenously for 4 h or more, once or twice per month, and once every 3 months Course of treatment. Results Twenty-five patients with bone metastases and multiple myeloma had pain relieved to varying degrees. There was no significant adverse reaction in 24 patients except 5 patients treated with dexamethasone given chill. Conclusion Pamidronate, one of the bisphosphonates, is safe and effective in the treatment of bone metastases caused by advanced tumor and multiple myeloma.