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已证明几种人类癌细胞株有1,25-二羟维生素D_3(1,25-(OH)_2D_3)的特异性高亲和力受体。1,25-(OH)_2D_3及其代谢物在体外能够抑制人类乳腺癌和恶性黑素瘤细胞株生长,并且1,25-(OH)_2D_3及其一种人工合成类似物能够延长用白血病细胞接种的白血病小鼠的存活期。本文研究了1,25-(OH)_2D_3及其同类物在小鼠体内对人类肿瘤的三个细胞株的异种移植瘤生长的抑制作用。 CBA/Lac小鼠出生后16～18天时切除胸腺,饲养18～21天后,经腹腔注射1-β-D阿糖呋喃嘧啶200mg/kg,48小时后用~(137)Csr射线
Several human cancer cell lines have been shown to have specific high affinity receptors for 1,25-dihydroxyvitamin D3 (1,25-(OH)2D_3). 1,25-(OH)_2D_3 and its metabolites can inhibit the growth of human breast cancer and malignant melanoma cell lines in vitro, and 1,25-(OH)_2D_3 and a synthetic analogue thereof can extend the use of leukemia cells. Survival of inoculated leukemia mice. This study investigated the inhibitory effects of 1,25-(OH)2D3 and its analogs on the growth of xenograft tumors in three human cell lines in mice. The thymus was removed 16-18 days after birth in CBA/Lac mice. After 18 to 21 days of feeding, 1-β-D arabinofuranpyrimidine 200 mg/kg was injected intraperitoneally and after 48 hours, ~(137)Csr rays were used.