本文观察了氯乙烯(VCM)对女工及雌性动物妊娠机能及胎儿(仔)发育的影响。共调查了236名氯乙烯作业女工,其中氯乙烯聚合工厂女工106名,车间空气中氯乙烯浓度经常超过卫生标准1—7倍;聚氯乙烯塑料加工女工130名,车间空气中VCM一般不超过卫生标准;以机械加工女工及女售货员239名为对照。结果为氯乙烯作业女工原发性不孕、自然流产及子代先天缺陷的发病率均不高。但氯乙烯聚合工厂女工的妊振高血压综合征发病较高。第一胎妊娠时的发病率为22.6％,相当于对照组女工的1.8倍。11名妊娠女工妊娠28～29周时,血色素含量及血小板计数低于对照女工(p<0.01)。大、小鼠于妊前2周及整个妊娠期以5000 ppm VCM吸入染毒时均未出现致畸,但胎鼠有皮下出血、骨骼发育迟缓、小鼠胎鼠体重低于对照组(p<0.05)。10 ppm染毒时无此等改变。结果认为女工可以参加空气中VCM浓度低于卫生标准的氯乙烯作业,但须加强对妊娠女工的劳动保护。 In this paper, the effects of VCM on gestational function and fetus development of female workers and female animals were observed. A total of 236 PVC women workers were surveyed, of whom 106 were women workers in the PVC polymerization plant. The VCI concentration in the workshop air often exceeded 1-7 times the hygiene standards. 130 PVC women workers were employed. The VCM in the workshop air generally did not exceed Health standards; mechanical workers and saleswoman 239 as a control. The results for the primary female infertility vinyl chloride job, spontaneous abortion and offspring birth defects are not high incidence. But vinyl chloride polymerization factory women’s pregnancy-induced hypertension syndrome higher incidence. The incidence of first-trimester pregnancies was 22.6%, equivalent to 1.8 times the control group of female workers. Eleven pregnant women gestational 28 to 29 weeks of gestation, hemoglobin content and platelet count was lower than the control female workers (p <0.01). The mice were not teratogenic when exposed to 5000 ppm VCM for 2 weeks and during the whole pregnancy. However, the fetal mice had subcutaneous hemorrhage and skeletal development retardation. The body weight of the mice was lower than that of the control group (p < 0.05). No such changes at 10 ppm exposure. As a result, women workers could participate in the VCM concentration in the air below the sanitation standard, but labor protection for pregnant women workers should be strengthened.