论文部分内容阅读
目的 建立SD大鼠肝癌侵袭胆管所致恶性梗阻性黄疸模型 ,初步评价其临床应用价值。方法 用Walker- 2 5 6瘤株近肝门部肝实质内接种 ,致高位胆管浸润转移造成狭窄 ,引起梗阻性黄疸。结果 本实验模型所致梗阻性黄疸表现及肝功能变化为慢性渐进性发展过程 ,病理切片光镜检查显示肝脏、胆管有癌细胞浸润和转移 ,同时肝内有不同程度的胆汁淤积表现。结论 此实验模型稳定、可重复 ,成功率为 73 .3 % ,其梗阻性黄疸表现特点与临床恶性梗阻性黄疸病人症状极其相似 ,对研究恶性梗阻性黄疸的病理生理机制及治疗具有一定价值。
Objective To establish a rat model of malignant obstructive jaundice induced by hepatocellular carcinoma (HCC) in the liver of SD rats and to evaluate the clinical value. Methods Inoculation of Walker-256 tumor near the hepatic portal parenchyma resulted in stenosis caused by high bile duct infiltration and metastasis, causing obstructive jaundice. Results The obstructive jaundice caused by this experimental model and the changes of liver function were chronic progressive development. The pathological examination showed that the liver and bile ducts had the infiltration and metastasis of cancer cells with varying degrees of cholestasis in the liver. Conclusion The experimental model is stable and reproducible with a success rate of 73.3%. The characteristics of obstructive jaundice are very similar to those of patients with clinical malignant obstructive jaundice, which is of great value in studying the pathophysiological mechanism and treatment of malignant obstructive jaundice.