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慢性支气管炎(慢支)患者呼吸道粘液量的明显增加及其流变学特性的改变,以致平衡遭到破坏.同时,纤毛数量的减少及功能降低也有重要作用.作者研究旨在观察慢支患者纤毛超微结构的改变。患者和方法:对30(男25,女5)例可疑支气管肺疾病患者进行经纤维支气管镜肺活检(内镜)。根据临床及内镜的表现分为3组:①对照组(8例):临床及内镜均无急、慢性支气管炎证据者,平均年龄58.1±13.6岁.②内镜慢支组(8例):内镜具有慢支表现而无临床症状者,平均年龄68.5±11.9岁。③临床慢支组(14例):内镜及临床均证实为慢支者,平均年龄65.8±10.1岁。内镜检查时至少从每例患者右主支气管取2块组织,立即固定、切片、染色、用光学显微镜和透射电镜观察。采用随机的方法至少观察300根纤毛,包括纤毛
Chronic bronchitis (chronic bronchitis) patients with respiratory tract mucus increased significantly and its rheological properties change, so that the balance is destroyed.At the same time, the number of cilia and reduced function also plays an important role in the study aimed to observe the patients with chronic bronchitis Ciliary ultrastructure changes. PATIENTS AND METHODS: Bronchofibroscopic lung biopsies (endoscopy) were performed on 30 (M25, F5) suspicious patients with bronchopulmonary disease. According to the clinical and endoscopic findings, the patients were divided into three groups: ① control group (8 cases): no evidence of acute or chronic bronchitis in both clinical and endoscopic cases, with an average age of 58.1 ± 13.6 years. ): Endoscopy with chronic bronchitis without clinical symptoms, the average age of 68.5 ± 11.9 years. ③ clinical chronic bronchitis group (14 cases): endoscopic and clinical confirmed as chronic bronchitis, with an average age of 65.8 ± 10.1 years. At least two tissues were taken from the right main bronchus of each patient during endoscopy, immediately fixed, sectioned, stained and observed with light microscopy and transmission electron microscopy. At least 300 cilia, including cilia, were observed using a randomized approach