目的探讨完整结肠系膜切除(CME)在结肠癌手术中的应用效果。方法选取2003年1—6月我院收治的结肠癌患者46例,将其随机分为对照组24例和观察组22例。观察组采用CME治疗,对照组采用传统的结肠癌手术治疗,比较两组患者吻合口瘘发生率、残端肿瘤残余率、局部复发率并统计患者3年和4年生存率。结果观察组患者吻合口瘘发生率、残端肿瘤残余率、局部复发率均低于对照组(P<0.05);观察组患者3年和4年生存率均高于对照组(P<0.05)。结论 CME治疗结肠癌安全有效,能达到系膜和淋巴组织切除最大化,延长患者生存时间。 Objective To investigate the effect of complete mesorectal excision (CME) in colon cancer surgery. Methods 46 patients with colon cancer admitted to our hospital from January to June in 2003 were randomly divided into control group (24 cases) and observation group (22 cases). The observation group was treated with CME. The control group was treated with conventional colon cancer surgery. The incidences of anastomotic fistula, residual tumor and local recurrence were compared between the two groups. The 3-year and 4-year survival rates were also calculated. Results The incidence of anastomotic fistula, the residual tumor residual rate and the local recurrence rate in the observation group were lower than those in the control group (P <0.05). The 3-year and 4-year survival rates in the observation group were significantly higher than those in the control group (P <0.05) . Conclusion CME is safe and effective in the treatment of colon cancer, maximizing the resection of mesangial and lymphoid tissues and prolonging the survival time of patients.