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目的分析溃疡性结肠炎患者粪便钙卫蛋白(fecal calprotectin,FCP)水平与病情严重程度的相关性。方法经肠镜及组织病理确诊的活动期溃疡性结肠炎患者100例为活动期组,恢复期溃疡性结肠炎患者40例为恢复期组,40例体检健康者为对照组,留取粪便,采用ELISA法检测3组FCP水平。结果活动期组患者FCP水平[(642.80±298.74)μg/g]明显高于恢复期[(74.19±31.24)μg/g)]及对照组[(59.31±44.06)μg/g](P<0.01),且中、重度活动期患者FCP[(1743.19±1365.73)、(596.37±325.20)μg/g]高于轻度患者[(172.40±150.19)μg/g],组间比较差异均有统计学意义(P<0.01);Spearman相关分析显示,FCP水平与溃疡性结肠炎患者病情严重度呈正相关(r=0.910,P=0.003)。结论 FCP水平与活动期溃疡性结肠炎患者病情呈正相关,检测FCP水平对病情评估有一定价值。
Objective To analyze the correlation between the level of fecal calprotectin (FCP) and the severity of the disease in patients with ulcerative colitis. Methods 100 patients with active ulcerative colitis diagnosed by enteroscopy and histopathology were active group, 40 patients with convalescent ulcerative colitis were in convalescent group, 40 healthy people were in control group, feces were collected, Three groups of FCP levels were detected by ELISA. Results The level of FCP in active group [(642.80 ± 298.74) μg / g] was significantly higher than that in convalescence [(74.19 ± 31.24) μg / g) and control group [(59.31 ± 44.06) μg / g] ), And the FCP (1743.19 ± 1365.73) and (596.37 ± 325.20) μg / g in moderate and severe active patients were significantly higher than those in mild patients [(172.40 ± 150.19) μg / g, respectively) (P <0.01). Spearman correlation analysis showed that the level of FCP was positively correlated with the severity of ulcerative colitis (r = 0.910, P = 0.003). Conclusion The FCP level is positively correlated with the activity of ulcerative colitis in active stage. The detection of FCP level has some value in disease evaluation.