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目的研讨脑梗塞患者合用阿斯匹林与硫酸氢氯吡格雷治疗的有效性、安全性。方法从我院2014年12月-2016年7月选取68例脑梗塞患者进行临床试验,并按随机自愿原则分配组别(34例/组),两组均实施常规基础治疗,Ⅰ组接受阿斯匹林用药,Ⅱ组同时接受阿斯匹林与硫酸氢氯吡格雷治疗,评估两组方案的有效性、安全性及对患者脑功能的改善情况。结果Ⅰ、Ⅱ组的临床总有效率各为73.53%与94.12%,组间相比,差异显著(P<0.05)。治疗前,两组的NIHSS评测值相比,差异不显著(P>0.05);治疗后,Ⅱ组的评测值与Ⅰ组相比,差异显著(P<0.05)。两组均未见严重药物副反应发生。结论对脑梗塞患者合用阿斯匹林与硫酸氢氯吡格雷治疗,方案既高效又安全,且可促进患者脑功能的恢复,值得加强推广。
Objective To study the efficacy and safety of aspirin and clopidogrel bisulfate in patients with cerebral infarction. Methods A total of 68 patients with cerebral infarction from December 2014 to July 2016 in our hospital were enrolled in the clinical trial. The patients were randomly assigned according to the principle of randomness (34 cases / group). Both groups received routine basic treatment, Spirin medication, Ⅱ group received both aspirin and clopidogrel bisulfate treatment to assess the effectiveness of both programs, safety and improvement of patients with brain function. Results The total clinical effective rates in groups Ⅰ and Ⅱ were 73.53% and 94.12% respectively, with significant difference (P <0.05). Before treatment, there was no significant difference between the two groups (P> 0.05). After treatment, the difference between the two groups was significant (P <0.05). No serious side effects occurred in both groups. Conclusions The combination of aspirin and clopidogrel bisulfate in patients with cerebral infarction is effective and safe, and can promote the recovery of patients’ brain function. It is worth to be promoted.