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[目的]探讨TPF方案治疗复发转移乳腺癌临床疗效。[方法]选取2006年5月～2008年5月复发转移乳腺癌患者36例,应用紫杉醇(TAX)联合小剂量顺铂(PDD)加氟尿嘧啶(5-Fu)方案(TPF方案)治疗,观察本组病例总有效率和毒性作用。[结果]总有效率72.2%。细胞减少发生率100%;血小板减少31.6%,恶心、呕吐63.8%,便秘19.1%,腹泻8.5%,脱发16.7%,局部静脉炎24.3%,肝功能异常37.9%,肾功能异常2.7%。[结论]采用紫杉醇加小剂量PDD和5-Fu联合治疗复发转移乳腺癌,获得较好的临床疗效,值得临床推广。
[Objective] To investigate the clinical efficacy of TPF regimen in the treatment of recurrent breast cancer. [Method] Totally 36 patients with recurrent breast cancer were recruited from May 2006 to May 2008. The patients were treated with paclitaxel (TAX) combined with low-dose cisplatin (PDD) plus 5-fluorouracil (TPF) Group total effective rate and toxicity. [Result] The total effective rate was 72.2%. The incidence of thrombocytopenia was 31.6%, nausea and vomiting 63.8%, constipation 19.1%, diarrhea 8.5%, hair loss 16.7%, local phlebitis 24.3%, liver dysfunction 37.9% and renal dysfunction 2.7%. [Conclusion] The combination of paclitaxel and small dose of PDD and 5-Fu in the treatment of recurrent and metastatic breast cancer has a good clinical efficacy and is worthy of clinical promotion.