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本研究应用特异性抗T、B淋巴细胞血清和抗IgG、IgM、IgA血清重复第一抗体荧光技术,α-萘酯酶组化染色对78例原发性肝癌局部浸润的淋巴细胞亚群、浆细胞、巨噬细胞进行了分类测定,以正常人和肝硬化的肝脏做为对照组,同时结合电镜观察和临床资料探讨了这些细胞在机体抗肝癌免疫中的作用。肝癌组织中浸润的细胞主要是T细胞(74％),其高度选择性集中在癌与无癌肝交界处,分别较肝硬化肝、正常肝高4.8倍和39.5倍。这些T细胞以不同方式攻击、杀伤癌细胞,局部淋巴细胞、巨噬细胞浸润是机体抗肝癌的特异性免疫反应。
In this study, specific anti-T, B lymphocyte serum and anti-IgG, IgM, and IgA serum were used to repeat the first antibody fluorescence technique, and α-naphthyl esterase histochemistry staining was performed on 78 patients with locally infiltrated lymphocyte subpopulations of primary liver cancer. The plasma cells and macrophages were classified and measured. The normal and cirrhotic livers were used as the control group. Combined with electron microscopy and clinical data, the role of these cells in anti-hepatocarcinoma immunity was explored. The infiltrating cells in hepatocellular carcinoma are mainly T cells (74%), which are highly selective and concentrated at the junction of cancer and non-cancerous liver, which are 4.8 times and 39.5 times higher than that of cirrhotic liver and normal liver respectively. These T cells attack and kill cancer cells in different ways. Local lymphocyte and macrophage infiltration are the specific immune responses of the body against liver cancer.