【《医学世界报道》1985年2月】近年美国俄克拉何马大学的 Charles T.Esmon 等人发现人类血液内含有两种具有抗凝血作用的蛋白质。它们均是维生素 K 依赖性血浆蛋白,一种称为 C 蛋白,另一种称为 S 蛋白。C 蛋白必须由凝血酶激活后才具有抗凝血的作用。Esmon 认为 C 蛋白可能作为一种反馈机制,可用来解释活体内的血液凝固作用为什么是一个自限过程。他们还发现内皮细胞表面有一种受体负责把无活性的 C 蛋白转变为活性型,并把这种受体称之为凝 [Medical World Report, February 1985] Charles T. Esmon of the University of Oklahoma in the United States in recent years found that human blood contains two proteins that have anticoagulant effects. They are all vitamin K-dependent plasma proteins, one called C protein and the other called S protein. The C protein must be activated by thrombin before it has anticoagulant effects. Esmon believes that protein C may act as a feedback mechanism and can explain why blood clotting in vivo is a self-limiting process. They also found that there is a receptor on the surface of endothelial cells responsible for converting inactive C protein into active form, and this receptor is called coagulation.