酮康唑是一种合成的广谱抗真菌药物。美国药物食品管理局最近已批准口服给药治疗如下真菌感染:食道念珠菌病、慢性皮肤念珠菌病、口腔炎、念珠菌尿、芽生菌病、球孢子菌病、着色真菌病、类球孢子菌病。本品不能用于深部的念珠菌病、曲菌病或毛霉菌病。酮康唑的作用是通过抑制真菌体内的14-脱甲基化反应,阻碍了羊毛甾醇转化成麦角甾醇,从而导致真菌膜通透性改变 Ketoconazole is a synthetic broad-spectrum antifungal drug. The U.S. Food and Drug Administration has recently approved oral administration for the treatment of the following fungal infections: esophageal candidiasis, chronic cutaneous candidiasis, stomatitis, Candida bacteria, blastomycosis, coccidiosis, pigmented mycosis, Mycosis. This product can not be used for deep candidiasis, aspergillosis or mold fungal disease. The effect of ketoconazole is to inhibit the conversion of lanosterol to ergosterol by inhibiting the 14-demethylation reaction in the fungus, resulting in a change in fungal membrane permeability